https://nova.newcastle.edu.au/vital/access/ /manager/Index en-au 5 Lymph node metastasis of primary endometrial cancers: Associated proteins revealed by MALDI imaging https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:50443 Wed 26 Jul 2023 08:33:30 AEST ]]> In Vivo cell fate tracing provides no evidence for mesenchymal to epithelial transition in adult fallopian tube and uterus https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:37510 Wed 19 Jan 2022 15:15:31 AEDT ]]> CYP19A1 fine-mapping and Mendelian randomization: estradiol is causal for endometrial cancer https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:24073 -11). SNP rs727479 was also among those most strongly associated with circulating E₂ concentrations in 2767 post-menopausal controls (P=7.4x10-8). The observed endometrial cancer odds ratio per rs727479 A-allele (1.15, CI=1.11-1.21) is compatible with that predicted by the observed effect on E₂ concentrations (1.09, CI=1.03-1.21), consistent with the hypothesis that endometrial cancer risk is driven by E₂. From 28 candidate-causal SNPs, 12 co-located with three putative gene-regulatory elements and their risk alleles associated with higher CYP19A1 expression in bioinformatical analyses. For both phenotypes, the associations with rs727479 were stronger among women with a higher BMI (Pinteraction=0.034 and 0.066 respectively), suggesting a biologically plausible gene-environment interaction.]]> Wed 19 Apr 2023 16:42:45 AEST ]]> Pathways to diagnosis of endometrial and ovarian cancer in the 45 and Up Study cohort https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:51044 Wed 16 Aug 2023 11:19:37 AEST ]]> Genetic risk score mendelian randomization shows that obesity measured as body mass index, but not waist:hip ratio, is causal for endometrial cancer https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30306 Wed 15 Dec 2021 16:09:28 AEDT ]]> Five endometrial cancer risk loci identified through genome-wide association analysis https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:27984 Wed 15 Dec 2021 16:06:55 AEDT ]]> Genetic variation and risk of endometrial cancer https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:6281 Wed 11 Apr 2018 16:43:21 AEST ]]> Polymorphisms in TP53 and MDM2 combined are associated with high grade endometrial cancer https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:6849 Wed 11 Apr 2018 16:39:01 AEST ]]> Management of ovarian and endometrial cancers in women belonging to HNPCC carrier families: review of the literature and results of cancer risk assessment in Polish HNPCC families https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:27601 Wed 11 Apr 2018 15:11:09 AEST ]]> Renin–angiotensin system gene polymorphisms and endometrial cancer https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:26763 Wed 11 Apr 2018 15:09:54 AEST ]]> The role of short tandem repeats in genetic susceptibility to breast and endometrial cancers https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:23272 Wed 11 Apr 2018 14:52:43 AEST ]]> Inhibition of extracellular matrix mediated TGF-β signalling suppresses endometrial cancer metastasis https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30784 Wed 11 Apr 2018 13:21:37 AEST ]]> Genome-wide association study of endometrial cancer in E2C2 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:20989 Wed 11 Apr 2018 11:20:08 AEST ]]> Genetic variants in MUTYH are not associated with endometrial cancer risk https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:6851 Wed 11 Apr 2018 10:50:17 AEST ]]> Patients' and clinicians' preferences for adjuvant chemotherapy in endometrial cancer: an ANZGOG substudy of the PORTEC-3 intergroup randomised trial https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:26036 Wed 11 Apr 2018 10:39:36 AEST ]]> Adipose-Derived VEGF–mTOR Signaling Promotes Endometrial Hyperplasia and Cancer: Implications for Obese Women https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:43015 Wed 09 Aug 2023 12:26:25 AEST ]]> Proteomic and functional characterization of intra-tumor heterogeneity in human endometrial cancer https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:50850 Wed 09 Aug 2023 09:39:07 AEST ]]> Phase 2 study of anastrozole in recurrent estrogen (ER)/progesterone (PR) positive endometrial cancer: the PARAGON trial – ANZGOG 0903 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45582 p = 0.002), cognitive functioning (45 vs 19%: p = 0.021), fatigue (47 vs 19%: p = 0.015) and global health status (42 vs 9%: p = 0.003). Conclusion: Although the objective response rate to anastrozole was relatively low, clinical benefit was observed in 44% of patients with ER/PR positive metastatic endometrial cancer and associated with an improvement in QOL.]]> Wed 02 Nov 2022 10:37:04 AEDT ]]> Endometrial stem/progenitor cells in endometrial regeneration, carcinogenesis and aging https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:33154 Wed 01 Sep 2021 11:58:48 AEST ]]> Toll-like receptor (TLR) and nucleosome-binding oligomerization domain (NOD) gene polymorphisms and endometrial cancer risk https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:9714 Tue 27 Aug 2024 12:22:09 AEST ]]> Development of a surgical competency assessment tool for sentinel lymph node dissection by minimally invasive surgery for endometrial cancer https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:41928 Tue 16 Aug 2022 14:47:15 AEST ]]> The renin-angiotensin system in endometrial cancer https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:35178 Tue 15 Dec 2020 10:46:03 AEDT ]]> Identification of nine new susceptibility loci for endometrial cancer https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:47028 Tue 13 Dec 2022 15:55:21 AEDT ]]> A common variant at the 14q32 endometrial cancer risk locus activates AKT1 through YY1 binding https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30271 Tue 13 Aug 2024 11:16:49 AEST ]]> A polymorphic repeat in the IGF1 promoter influences the risk of endometrial cancer https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:26531 Thu 28 Oct 2021 12:37:29 AEDT ]]> A novel polymorphic repeat in the upstream regulatory region of the estrogen-induced gene EIG121 is not associated with the risk of developing breast or endometrial cancer https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30240 EIG121) has been associated with breast and endometrial cancers, but its mechanism of action remains unknown. In a genome-wide search for tandem repeats, we found that EIG121 contains a short tandem repeat (STR) in its upstream regulatory region which has the potential to alter gene expression. The presence of this STR has not previously been analysed in relation to breast or endometrial cancer risk. Results: In this study, the lengths of this STR were determined by PCR, fragment analysis and sequencing using DNA from 223 breast cancer patients, 204 endometrial cancer patients and 220 healthy controls to determine if they were associated with the risk of developing breast or endometrial cancer. We found this repeat to be highly variable with the number of copies of the AG motif ranging from 27 to 72 and having a bimodal distribution. No statistically significant association was identified between the length of this STR and the risk of developing breast or endometrial cancer or age at diagnosis. Conclusions: The STR in the upstream regulatory region of EIG121 is highly polymorphic, but is not associated with the risk of developing breast or endometrial cancer in the cohorts analysed here. While this polymorphic STR in the regulatory region of EIG121 appears to have no impact on the risk of developing breast or endometrial cancer, its association with disease recurrence or overall survival remains to be determined.]]> Thu 28 Oct 2021 12:35:27 AEDT ]]> Role of the prorenin receptor in endometrial cancer cell growth https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45233 Thu 27 Oct 2022 13:10:07 AEDT ]]> The emerging role of the microenvironment in endometrial cancer https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:36332 Thu 24 Mar 2022 11:36:03 AEDT ]]> Pelvic floor functional outcomes after total abdominal vs total laparoscopic hysterectomy for endometrial cancer https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:34527 Thu 17 Feb 2022 09:27:02 AEDT ]]> Oestrogen fuels the growth of endometrial hyperplastic lesions initiated by overactive Wnt/β-catenin signalling https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:43322 Thu 15 Sep 2022 14:43:38 AEST ]]> Weight and weight control behaviors during long-term endometrial cancer survivorship: Results of the Laparoscopic Approach to Cancer of the Endometrium long-term follow-up study https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:49343 Thu 11 May 2023 15:52:18 AEST ]]> Expression of renin–angiotensin system (RAS) components in endometrial cancer https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:26776 Thu 11 Apr 2019 13:18:13 AEST ]]> Candidate locus analysis of the TERT-CLPTM1L cancer risk region on chromosome 5p15 identifies multiple independent variants associated with endometrial cancer risk https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:28088 −6 to P = 7.7 × 10−5). Only one falls into a haplotype previously associated with other cancer types (rs7705526, in TERT intron 1), and this SNP has been shown to alter TERT promoter activity. One of the novel associations (rs13174814) maps to a second region in the TERT promoter and the other (rs62329728) is in the promoter region of CLPTM1L; neither are correlated with previously reported cancer-associated SNPs. Using TCGA RNASeq data, we found significantly increased expression of both TERT and CLPTM1L in endometrial cancer tissue compared with normal tissue (TERTP = 1.5 × 10−18, CLPTM1LP = 1.5 × 10−19). Our study thus reports a novel endometrial cancer risk locus and expands the spectrum of cancer types associated with genetic variation at 5p15, further highlighting the importance of this region for cancer susceptibility.]]> Thu 08 Aug 2024 15:35:23 AEST ]]> Estrogen receptor polymorphisms and the risk of endometrial cancer https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:6850 Sat 24 Mar 2018 10:23:19 AEDT ]]> Screening for gynaecological conditions https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:7711 Sat 24 Mar 2018 08:41:39 AEDT ]]> Polymorphisms in genes of the steroid hormone biosynthesis and metabolism pathways and endometrial cancer risk https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:9354 Sat 24 Mar 2018 08:36:33 AEDT ]]> Genome-wide association study identifies a possible susceptibility locus for endometrial cancer https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:17481 Sat 24 Mar 2018 08:04:10 AEDT ]]> Comprehensive genetic assessment of the ESR1 locus identifies a risk region for endometrial cancer https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:26799 Sat 24 Mar 2018 07:36:26 AEDT ]]> Lower preoperative quality of life increases postoperative risk of adverse events in women with endometrial cancer: results from the LACE trial https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:27255 Sat 24 Mar 2018 07:29:12 AEDT ]]> Evidence of a causal association between insulinemia and endometrial cancer: a Mendelian randomization analysis https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:27532 Sat 24 Mar 2018 07:28:58 AEDT ]]> Rare germline copy number deletions of likely functional importance are implicated in endometrial cancer predisposition https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:26944 0.05), but cases presented with an excess of rare germline deletions overlapping likely functional genomic regions including genes (P = 8 x 10-10), CpG islands (P = 1 x 10-7) and sno/miRNAs regions (P = 3 x 10-9). On average, at least one additional gene and two additional CpG islands were disrupted by rare deletions in cases compared to controls. The most pronounced difference was that over 30 sno/miRNAs were disrupted by rare deletions in cases for every single disruption event in controls. A total of 13 DNA repair genes were disrupted by rare deletions in 19/1,209 cases (1.6 %) compared to one gene in 1/528 controls (0.2 %; P = 0.007), and this increased DNA repair gene loss in cases persisted after excluding five individuals carrying CNVs disrupting mismatch repair genes MLH1, MSH2 and MSH6 (P = 0.03). There were 34 miRNA regions deleted in at least one case but not in controls, the most frequent of which encompassed hsa-mir-661 and hsa-mir-203. Our study implicates rare germline deletions of functional and regulatory regions as possible mechanisms conferring endometrial cancer risk, and has identified specific regulatory elements as candidates for further investigation.]]> Sat 24 Mar 2018 07:27:02 AEDT ]]> GWAS meta-analysis of 16 852 women identifies new susceptibility locus for endometrial cancer https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:27911 −8) at 6p22.3 (rs1740828; P = 2.29 x 10−8, OR = 1.20), providing evidence of an additional region of interest for genetic susceptibility to endometrial cancer.]]> Sat 24 Mar 2018 07:24:36 AEDT ]]> Age-related mTOR in ovarian and endometrial cancers https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:32907 Mon 23 Sep 2019 13:50:52 AEST ]]> Role of Wnt signalling in endometrial homeostasis and cancer https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:32344 Mon 23 Sep 2019 12:47:41 AEST ]]> The role of intrauterine tissue renin-angiotensin systems in pregnancy and reproductive health https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:34766 Mon 23 Sep 2019 12:39:29 AEST ]]> Genetic overlap between endometriosis and endometrial cancer: Evidence from cross-disease genetic correlation and GWAS meta-analyses https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:48810 Mon 10 Apr 2023 10:28:37 AEST ]]> Role of microenvironment in endometrial cancer progression, metastasis, and drug resistance https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:32397 Mon 06 Feb 2023 11:55:11 AEDT ]]> Annexin A2 and alpha actinin 4 expression correlates with metastatic potential of primary endometrial cancer https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:34334 Mon 04 Mar 2019 12:02:47 AEDT ]]> The preventable burden of endometrial and ovarian cancers in Australia: a pooled cohort study https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:35870 Fri 21 Oct 2022 11:25:56 AEDT ]]> Cross-Cancer Genome-Wide Association Study of Endometrial Cancer and Epithelial Ovarian Cancer Identifies Genetic Risk Regions Associated with Risk of Both Cancers https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:47283 Fri 13 Jan 2023 10:24:53 AEDT ]]> Multi-tissue transcriptome-wide association study identifies eight candidate genes and tissue-specific gene expression underlying endometrial cancer susceptibility https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:47870 Fri 03 Feb 2023 14:42:59 AEDT ]]>